Hyaluronan metabolic process

Across TCGA patient cohorts, RNA activity of the Hyaluronan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP1B1, FOLR2, and MS4A6A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hyaluronan metabolic process activity versus CYP1B1 in OV (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CYP1B1 →	+1.729	+0.207	<.001	<.001	3	7
OV	FOLR2 →	+0.968	+0.183	.001	<.001	3	7
OV	MS4A6A →	+1.011	+0.218	.002	<.001	3	6
OV	EFEMP1 →	+1.787	+0.230	<.001	<.001	3	6
GBM	F13A1 →	+2.383	+0.267	<.001	<.001	3	6
LSCC	TRAP1 →	-0.453	-0.099	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030212 vs CYP1B1 — OV

Explore this scatter interactively →