Hyaluronan metabolic process

Across TCGA cell cohorts, RNA activity of the Hyaluronan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRD9, ZSCAN22, and LSM2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BRD9 grouped by Hyaluronan metabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BRD9 →	-0.731	-0.856	.001	.001	3	4
BLOOD_Myeloma	ZSCAN22 →	+0.791	+1.335	.006	.004	3	3
LUNG_SCLC	LSM2 →	-0.711	-1.191	.003	.005	3	3
SKIN	ZFYVE21 →	-0.523	-0.816	.001	<.001	3	3
BLOOD_Leukemia	MSMO1 →	-1.598	-1.017	.001	.006	3	3
BLOOD_Lymphoma	CCNQ →	-1.252	-1.634	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BRD9 by Hyaluronan metabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →