Hyaluronan metabolic process

Across TCGA cell cohorts, RNA activity of the Hyaluronan metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MKKS, TAL1, and DLX5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MKKS grouped by Hyaluronan metabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MKKS →	+0.192	+0.181	<.001	.001	3	4
SOFT_TISSUE	TAL1 →	+0.134	+0.172	.006	.001	3	4
CNS	DLX5 →	-0.182	-0.103	.002	<.001	3	4
LUNG_NSCLC_LUAD	RAB17 →	-0.156	-0.121	.003	.004	3	4
BLOOD_Lymphoma	SH3TC2 →	+0.217	+0.151	.003	<.001	3	4
BREAST	PXYLP1 →	+0.120	+0.111	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MKKS by Hyaluronan metabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →