Heparan sulfate proteoglycan catabolic process

Across TCGA patient cohorts, RNA activity of the Heparan sulfate proteoglycan catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LRMDA, BTK, and APOBR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heparan sulfate proteoglycan catabolic process activity versus LRMDA in GBM (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LRMDA →	+0.620	+0.083	<.001	<.001	3	5
LSCC	BTK →	+0.508	+0.053	<.001	.002	3	5
GBM	APOBR →	+0.540	+0.079	<.001	<.001	3	5
GBM	ARHGAP25_T443 →	+0.466	+0.045	.002	.001	3	5
GBM	PYCARD →	+0.438	+0.064	<.001	<.001	3	5
COAD	RRBP1_T275 →	-0.513	-0.035	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030200 vs LRMDA — GBM

Explore this scatter interactively →