Heparan sulfate proteoglycan catabolic process

Across TCGA cell cohorts, RNA activity of the Heparan sulfate proteoglycan catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNS, PAK1IP1, and GMDS, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heparan sulfate proteoglycan catabolic process activity versus GNS in BLOOD_Leukemia (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GNS →	+1.152	+0.828	.001	.009	3	7
OESOPHAGUS	PAK1IP1 →	-0.856	-0.906	.001	.002	3	3
OESOPHAGUS	GMDS →	-1.552	-1.186	<.001	.001	3	3
OESOPHAGUS	GALNT12 →	-2.245	-1.064	.005	.002	2	4
OESOPHAGUS	RELCH →	-0.695	-1.012	.001	.001	3	3
LUNG_SCLC	TRADD →	+0.663	+0.726	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030200 vs GNS — BLOOD_Leukemia

Explore this scatter interactively →