B cell differentiation

Across TCGA patient cohorts, RNA activity of the B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL2RB, IL10RA, and ITK, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, B cell differentiation activity versus IL2RB in SCLC (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	IL2RB →	+2.427	+0.159	<.001	<.001	3	34
SKCM	IL10RA →	+2.127	+0.069	<.001	<.001	3	34
SCLC	ITK →	+1.984	+0.168	<.001	<.001	3	34
SKCM	CXorf21 →	+1.568	+0.071	<.001	<.001	3	34
LAML	CCR2 →	+2.023	+0.044	<.001	<.001	3	34
SCLC	NCKAP1L →	+2.358	+0.128	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030183 vs IL2RB — SCLC

Explore this scatter interactively →