Negative regulation of Wnt signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST6GAL2, PCMTD1, and OCEL1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of Wnt signaling pathway activity versus ST6GAL2 in COAD (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ST6GAL2 →	+0.567	+0.464	.002	.002	3	2
COAD	PCMTD1 →	+0.385	+0.591	.003	.007	3	2
COAD	OCEL1 →	+0.365	+0.636	.001	<.001	3	2
COAD	TRIM9 →	+0.189	+0.411	.007	.006	3	1
COAD	BEX4 →	+0.720	+0.567	.001	.001	3	1
COAD	CRX →	+0.012	+0.539	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030178 vs ST6GAL2 — COAD

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