Negative regulation of Wnt signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP23B, STX2, and PPIE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MMP23B grouped by Negative regulation of Wnt signaling pathway-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MMP23B →	+0.694	+0.239	.003	<.001	3	5
LARGE_INTESTINE	STX2 →	-0.953	-0.145	.005	.006	3	4
BLOOD_Myeloma	PPIE →	+0.726	+0.147	<.001	.002	2	5
BLOOD_Lymphoma	SSBP3 →	+2.307	+0.259	.008	<.001	3	3
BLOOD_Leukemia	OCM →	+0.087	+0.156	.007	.008	3	3
BLOOD_Leukemia	CCZ1 →	+0.808	+0.176	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MMP23B by Negative regulation of Wnt signaling pathway activity — BLOOD_Myeloma

Explore this box plot interactively →