Positive regulation of Wnt signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C7, DDIT4L, and GNPNAT1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of Wnt signaling pathway activity versus C7 in OV (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C7 →	+2.262	+0.214	.001	<.001	3	3
COAD	DDIT4L →	+0.490	+0.569	.006	.003	3	3
PDAC	GNPNAT1 →	-0.642	-0.549	.008	<.001	3	2
PDAC	CHRM5 →	-0.280	-0.624	.008	.009	3	2
PDAC	CCDC157 →	-0.205	-0.619	.005	.009	3	2
PDAC	TOMM20L →	-0.549	-0.662	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030177 vs C7 — OV

Explore this scatter interactively →