Positive regulation of Wnt signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VIPR1, MPZL3, and PRSS22, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VIPR1 grouped by Positive regulation of Wnt signaling pathway-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	VIPR1 →	+2.983	+0.188	<.001	<.001	3	5
OVARY	MPZL3 →	+1.691	+0.166	<.001	<.001	3	5
OVARY	PRSS22 →	+2.613	+0.149	.003	.007	3	5
LUNG_NSCLC_LUAD	CDC42BPG →	+1.215	+0.100	<.001	<.001	3	5
LUNG_NSCLC_LUAD	ERBB3 →	+2.035	+0.126	.005	.003	3	5
PANCREAS	TPX2 →	-1.012	-0.192	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VIPR1 by Positive regulation of Wnt signaling pathway activity — URINARY_TRACT

Explore this box plot interactively →