Positive regulation of Wnt signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYNE2, MTMR1, and SUCLG2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of Wnt signaling pathway activity versus SYNE2 in BLOOD_Leukemia (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SYNE2 →	+2.151	+0.189	.002	.001	3	6
LARGE_INTESTINE	MTMR1 →	+1.016	+0.187	<.001	<.001	3	6
LUNG_SCLC	SUCLG2 →	-1.483	-0.185	<.001	.002	2	7
LUNG_SCLC	WFDC2 →	+4.058	+0.265	<.001	<.001	3	6
OESOPHAGUS	KRT6A →	+5.805	+0.272	.003	<.001	3	5
STOMACH	KIF22 →	+0.705	+0.255	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030177 vs SYNE2 — BLOOD_Leukemia

Explore this scatter interactively →