Regulation of DNA-templated DNA replication initiation

Across TCGA cell cohorts, RNA activity of the Regulation of DNA-templated DNA replication initiation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM5, CDCA7, and KHSRP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA-templated DNA replication initiation activity versus MCM5 in LIVER (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MCM5 →	+0.848	+0.449	.008	.001	3	8
URINARY_TRACT	CDCA7 →	+1.090	+0.567	.002	.008	3	7
OVARY	KHSRP →	+0.752	+0.446	.002	.009	3	6
KIDNEY	TAB1 →	+1.514	+0.430	.001	.004	3	6
LARGE_INTESTINE	METTL21A →	+0.714	+0.366	.001	<.001	3	6
KIDNEY	PES1 →	+0.711	+0.318	.007	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030174 vs MCM5 — LIVER

Explore this scatter interactively →