Platelet activation

Across TCGA patient cohorts, RNA activity of the Platelet activation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEX26-AS1, VGLL3, and DACT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet activation activity versus TEX26-AS1 in HNSC (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TEX26-AS1 →	+0.352	+0.192	.008	.001	3	6
CCRCC	VGLL3 →	+1.183	+0.383	.007	<.001	3	6
UCEC	DACT1 →	+1.596	+0.346	<.001	.006	3	6
OV	ABCA6 →	+0.710	+0.215	<.001	<.001	3	6
CCRCC	EBF1 →	+1.146	+0.387	.009	.004	3	6
OV	ADAMTS5 →	+0.964	+0.205	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030168 vs TEX26-AS1 — HNSC

Explore this scatter interactively →