Platelet activation

Across TCGA cell cohorts, RNA activity of the Platelet activation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF25, DZIP1L, and PLPPR2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet activation activity versus ZNF25 in LUNG_NSCLC_LUAD (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZNF25 →	+0.812	+0.213	<.001	.001	3	6
URINARY_TRACT	DZIP1L →	+2.268	+0.460	.002	<.001	3	6
LARGE_INTESTINE	PLPPR2 →	+0.744	+0.178	.008	.004	3	5
LARGE_INTESTINE	RORC →	-1.284	-0.282	.001	<.001	3	5
LARGE_INTESTINE	ERBB3 →	-1.178	-0.204	.001	<.001	3	5
LARGE_INTESTINE	NAV3 →	+1.817	+0.287	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030168 vs ZNF25 — LUNG_NSCLC_LUAD

Explore this scatter interactively →