Proteoglycan catabolic process

Across TCGA patient cohorts, RNA activity of the Proteoglycan catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIRP cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IDUA, ATG16L2, and SGSH, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proteoglycan catabolic process activity versus IDUA in KIRP (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	IDUA →	+1.173	+0.088	<.001	<.001	3	28
KIRP	ATG16L2 →	+1.092	+0.083	<.001	<.001	3	26
LAML	SGSH →	+1.098	+0.060	<.001	<.001	3	26
KIRP	TTLL3 →	+1.473	+0.084	<.001	<.001	3	25
KIRP	APBB3 →	+1.014	+0.080	<.001	<.001	3	24
SCLC	TMEM175 →	+1.172	+0.186	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030167 vs IDUA — KIRP

Explore this scatter interactively →