Proteoglycan catabolic process

Across TCGA cell cohorts, RNA activity of the Proteoglycan catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC13, JOSD2, and IRF9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEC13 grouped by Proteoglycan catabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SEC13 →	+0.815	+1.551	<.001	<.001	3	4
BLOOD_Leukemia	JOSD2 →	-1.351	-1.206	.006	.003	3	4
BLOOD_Leukemia	IRF9 →	-0.979	-0.898	<.001	.006	3	4
CNS	TMEM97 →	+0.935	+1.007	.003	<.001	3	4
CNS	KAT7 →	+0.593	+0.889	<.001	.002	3	4
BREAST	SLC46A1 →	+1.007	+0.853	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEC13 by Proteoglycan catabolic process activity — LIVER

Explore this box plot interactively →