Proteoglycan catabolic process

Across TCGA cell cohorts, RNA activity of the Proteoglycan catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRTAP, MAGED2, and DDOST, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proteoglycan catabolic process activity versus CRTAP in KIDNEY (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CRTAP →	+1.056	+0.484	.008	.004	3	5
LUNG_SCLC	MAGED2 →	+1.001	+0.979	<.001	<.001	3	5
BLOOD_Leukemia	DDOST →	+0.735	+1.113	<.001	<.001	3	5
BONE	DIPK1A →	+1.940	+1.475	.005	.003	3	5
BLOOD_Lymphoma	GPC1 →	+1.064	+1.191	.003	.006	3	5
BLOOD_Leukemia	GRN →	+1.717	+1.081	.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030167 vs CRTAP — KIDNEY

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