Proteoglycan biosynthetic process

Across TCGA patient cohorts, RNA activity of the Proteoglycan biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XYLT2, MYCBP2_S2920, and PNISR_S290, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proteoglycan biosynthetic process activity versus XYLT2 in CCRCC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	XYLT2 →	+0.589	+0.626	<.001	<.001	3	4
OV	MYCBP2_S2920 →	-2.034	-0.450	<.001	<.001	3	3
OV	PNISR_S290 →	-1.112	-0.175	<.001	<.001	3	3
LSCC	SAMHD1_S27 →	-1.009	-0.280	.001	.008	3	3
UCEC	SRRM1_S414 →	-1.006	-0.828	<.001	.001	3	3
GBM	THBS1 →	+1.012	+0.472	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030166 vs XYLT2 — CCRCC

Explore this scatter interactively →