Proteoglycan biosynthetic process

Across TCGA cell cohorts, RNA activity of the Proteoglycan biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTNNB1, ASB6, and HELLS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTNNB1 grouped by Proteoglycan biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CTNNB1 →	-1.468	-0.752	<.001	<.001	3	6
OESOPHAGUS	ASB6 →	-0.102	-1.347	.008	.002	3	4
LUNG_NSCLC_LUAD	HELLS →	+0.095	+0.612	<.001	.002	3	4
LUNG_NSCLC_LUAD	GK2 →	+0.086	+0.807	.009	.004	3	4
SKIN	NDST3 →	-0.126	-0.686	.005	.005	2	5
SOFT_TISSUE	ARHGAP29 →	-0.172	-1.068	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTNNB1 by Proteoglycan biosynthetic process activity — LARGE_INTESTINE

Explore this box plot interactively →