Proteoglycan biosynthetic process

Across TCGA cell cohorts, RNA activity of the Proteoglycan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LSM3, TMEM182, and ZXDC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LSM3 grouped by Proteoglycan biosynthetic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LSM3 →	+0.490	+1.177	.004	<.001	3	4
CNS	TMEM182 →	+0.542	+0.779	.008	.003	3	3
CNS	ZXDC →	+0.516	+1.056	.002	.001	3	3
OVARY	SUCLG1 →	+0.715	+0.930	<.001	.005	3	3
LARGE_INTESTINE	C11orf45 →	+0.897	+0.893	.002	.005	3	3
LARGE_INTESTINE	ALG1L →	+1.927	+0.779	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LSM3 by Proteoglycan biosynthetic process activity — SOFT_TISSUE

Explore this box plot interactively →