Proteoglycan biosynthetic process

Across TCGA cell cohorts, RNA activity of the Proteoglycan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UGDH, GSR, and TRAP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proteoglycan biosynthetic process activity versus UGDH in STOMACH (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	UGDH →	+1.849	+1.407	.005	.007	2	9
STOMACH	GSR →	+1.883	+1.580	<.001	<.001	3	7
STOMACH	TRAP1 →	+1.415	+1.345	.003	.006	3	6
UPPER_AERODIGESTIVE_TRACT	DUSP10 →	-1.781	-1.321	.003	.003	3	6
UPPER_AERODIGESTIVE_TRACT	PCBP2 →	+0.620	+1.186	.003	.003	3	6
UPPER_AERODIGESTIVE_TRACT	VDAC1 →	+1.175	+1.349	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030166 vs UGDH — STOMACH

Explore this scatter interactively →