Pancreatic juice secretion

Across TCGA patient cohorts, RNA activity of the Pancreatic juice secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GNG7, ATAD2_S342, and HMGB3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pancreatic juice secretion activity versus GNG7 in LSCC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GNG7 →	+0.685	+0.104	<.001	<.001	3	7
LSCC	ATAD2_S342 →	-0.990	-0.113	<.001	<.001	3	6
LSCC	HMGB3 →	-0.723	-0.092	<.001	<.001	2	7
LSCC	EVL_S283 →	+1.070	+0.116	<.001	<.001	3	6
LSCC	RFC2 →	-0.473	-0.110	<.001	<.001	3	5
LSCC	RPL12_S38 →	-0.798	-0.070	.002	.009	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030157 vs GNG7 — LSCC

Explore this scatter interactively →