Pancreatic juice secretion

Across TCGA patient cohorts, RNA activity of the Pancreatic juice secretion pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLIC6, CCM2L, and FMN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pancreatic juice secretion activity versus CLIC6 in CCRCC (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CLIC6 →	+0.918	+0.395	.002	.006	3	4
CCRCC	CCM2L →	-0.706	-0.651	.002	.001	3	3
CCRCC	FMN1 →	+0.633	+0.616	<.001	.002	3	3
CCRCC	DPEP2NB →	-0.101	-0.488	<.001	.002	3	3
BRCA	TFF1 →	+3.240	+0.364	.001	.004	3	3
COAD	NBPF3 →	+0.469	+0.142	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030157 vs CLIC6 — CCRCC

Explore this scatter interactively →