Pancreatic juice secretion

Across TCGA cell cohorts, RNA activity of the Pancreatic juice secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNK1, COPA, and NRBP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WNK1 grouped by Pancreatic juice secretion-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WNK1 →	-0.488	-0.225	<.001	<.001	3	10
LUNG_SCLC	COPA →	-0.704	-0.458	.001	<.001	3	9
STOMACH	NRBP1 →	-0.323	-0.322	.006	.004	2	6
LIVER	CTH →	+0.126	+0.189	.005	.004	3	4
LIVER	SAMD4B →	-0.234	-0.192	.007	.002	3	4
LIVER	DUSP29 →	+0.271	+0.226	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WNK1 by Pancreatic juice secretion activity — LARGE_INTESTINE

Explore this box plot interactively →