Pancreatic juice secretion

Across TCGA cell cohorts, RNA activity of the Pancreatic juice secretion pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEL, AQP1, and SYTL1, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pancreatic juice secretion activity versus CEL in PANCREAS (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CEL →	-1.322	-0.284	<.001	<.001	3	15
LIVER	AQP1 →	-2.596	-0.273	<.001	<.001	3	13
OVARY	SYTL1 →	-2.170	-0.224	<.001	<.001	3	8
SKIN	COPA →	+0.895	+0.184	<.001	<.001	3	8
URINARY_TRACT	RAPGEFL1 →	-2.049	-0.236	<.001	<.001	3	8
LARGE_INTESTINE	CYP2D6 →	-0.889	-0.240	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030157 vs CEL — PANCREAS

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