Protein import into mitochondrial matrix

Across TCGA patient cohorts, RNA activity of the Protein import into mitochondrial matrix pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM4, NDC80, and MCM6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein import into mitochondrial matrix activity versus MCM4 in LUAD (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MCM4 →	+0.513	+0.032	<.001	.002	3	7
HNSC	NDC80 →	+0.386	+0.052	<.001	.007	3	6
LUAD	MCM6 →	+0.523	+0.031	<.001	.004	3	6
OV	CACYBP →	+0.362	+0.037	.001	.003	3	5
BRCA	CCNB1 →	+0.660	+0.037	<.001	<.001	3	5
LUAD	CENPF_S3023 →	+1.076	+0.030	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030150 vs MCM4 — LUAD

Explore this scatter interactively →