Protein import into mitochondrial matrix

Across TCGA patient cohorts, RNA activity of the Protein import into mitochondrial matrix pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFBR2, CD36, and GSN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein import into mitochondrial matrix activity versus TGFBR2 in BRCA (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TGFBR2 →	-0.620	-0.236	<.001	<.001	3	6
BRCA	CD36 →	-1.284	-0.273	<.001	<.001	3	6
GBM	GSN →	-0.678	-0.168	.007	.002	3	6
CCRCC	TPPP3 →	-0.965	-0.228	<.001	.001	3	6
BRCA	ABCA9 →	-0.578	-0.229	.003	<.001	3	6
LUAD	STARD8 →	-0.495	-0.208	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030150 vs TGFBR2 — BRCA

Explore this scatter interactively →