Protein import into mitochondrial matrix

Across TCGA cell cohorts, RNA activity of the Protein import into mitochondrial matrix pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARPC4, MOAP1, and ZNF620, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARPC4 grouped by Protein import into mitochondrial matrix-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ARPC4 →	-0.961	-0.627	.005	<.001	3	4
BREAST	MOAP1 →	+0.727	+0.191	.003	.008	3	4
BREAST	ZNF620 →	+0.804	+0.249	.009	.007	3	4
BREAST	NPIPB13 →	+0.525	+0.220	.005	<.001	3	4
OESOPHAGUS	LTB4R →	+1.390	+0.420	.008	.001	3	3
LIVER	ASAP3 →	-1.748	-0.336	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARPC4 by Protein import into mitochondrial matrix activity — BLOOD_Lymphoma

Explore this box plot interactively →