Protein import into mitochondrial matrix

Across TCGA cell cohorts, RNA activity of the Protein import into mitochondrial matrix pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC13, CCDC107, and MRPL27, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein import into mitochondrial matrix activity versus CCDC13 in LUNG_NSCLC_LUSC (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CCDC13 →	-0.451	-0.216	.005	.001	3	5
CNS	CCDC107 →	-0.897	-0.150	.001	<.001	3	5
KIDNEY	MRPL27 →	-1.076	-0.309	.001	.003	3	4
KIDNEY	CENPX →	-1.437	-0.278	<.001	.001	3	4
OVARY	NELFB →	-0.576	-0.268	<.001	.001	3	4
OVARY	CLIC1 →	-0.998	-0.197	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030150 vs CCDC13 — LUNG_NSCLC_LUSC

Explore this scatter interactively →