Natural killer cell activation

Across TCGA patient cohorts, RNA activity of the Natural killer cell activation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK8, ANKRD44, and ARHGAP45, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Natural killer cell activation activity versus DOCK8 in LSCC (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DOCK8 →	+0.481	+0.043	<.001	<.001	3	10
LSCC	ANKRD44 →	+0.447	+0.054	<.001	<.001	3	10
GBM	ARHGAP45 →	+0.540	+0.057	<.001	<.001	3	10
GBM	DEF6 →	+0.550	+0.049	<.001	<.001	3	10
LSCC	STK10 →	+0.390	+0.042	<.001	<.001	3	9
UCEC	RCSD1 →	+0.543	+0.058	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030101 vs DOCK8 — LSCC

Explore this scatter interactively →