Natural killer cell activation

Across TCGA patient cohorts, RNA activity of the Natural killer cell activation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYTH4, ZBP1, and FAM78A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Natural killer cell activation activity versus CYTH4 in PDAC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CYTH4 →	+0.485	+0.232	<.001	<.001	3	7
PDAC	ZBP1 →	+0.630	+0.165	.003	.003	3	7
LSCC	FAM78A →	+0.483	+0.119	<.001	.007	3	7
PDAC	ITGAL →	+0.585	+0.203	<.001	<.001	3	7
CCRCC	IL12RB1 →	+0.475	+0.194	.003	.004	3	7
GBM	GNGT2 →	+0.312	+0.119	.006	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030101 vs CYTH4 — PDAC

Explore this scatter interactively →