Natural killer cell activation

Across TCGA cell cohorts, RNA activity of the Natural killer cell activation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VAMP7, EXOC2, and ZNF786, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Natural killer cell activation activity versus VAMP7 in SKIN (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	VAMP7 →	+0.987	+0.184	<.001	.007	3	5
LARGE_INTESTINE	EXOC2 →	+0.557	+0.178	.001	.001	3	4
BLOOD_Myeloma	ZNF786 →	-1.015	-0.240	<.001	.001	3	4
BLOOD_Myeloma	PSMB10 →	+1.121	+0.234	.002	.002	3	4
BLOOD_Leukemia	NFKBIE →	+0.827	+0.184	<.001	<.001	3	4
BLOOD_Leukemia	TMEM25 →	-1.520	-0.163	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030101 vs VAMP7 — SKIN

Explore this scatter interactively →