Regulation of endocytosis

Across TCGA cell cohorts, RNA activity of the Regulation of endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEF2, SDC4, and MARS2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endocytosis activity versus EEF2 in URINARY_TRACT (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	EEF2 →	-0.847	-0.290	<.001	<.001	3	9
BONE	SDC4 →	+3.316	+0.254	<.001	<.001	3	9
OESOPHAGUS	MARS2 →	-1.032	-0.187	.004	.006	3	9
PANCREAS	TFB2M →	-0.756	-0.234	<.001	.003	3	8
BONE	TRAP1 →	-1.784	-0.272	<.001	<.001	3	8
URINARY_TRACT	HSPD1 →	-1.061	-0.186	<.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030100 vs EEF2 — URINARY_TRACT

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