Protein repair

Across TCGA patient cohorts, RNA activity of the Protein repair pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, SVIL, and TPM1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein repair activity versus RSU1 in UCEC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RSU1 →	+0.461	+0.071	<.001	<.001	3	9
GBM	SVIL →	+0.507	+0.070	<.001	.001	3	9
COAD	TPM1 →	+0.905	+0.052	<.001	<.001	3	9
UCEC	ILK →	+0.515	+0.061	<.001	<.001	3	9
UCEC	MSRB3 →	+0.831	+0.081	<.001	<.001	3	9
UCEC	MYLK →	+0.833	+0.059	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030091 vs RSU1 — UCEC

Explore this scatter interactively →