Protein repair

Across TCGA cell cohorts, RNA activity of the Protein repair pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP72, PSMC3IP, and DNA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CEP72 grouped by Protein repair-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CEP72 →	+0.992	+1.843	.008	.008	3	4
BONE	PSMC3IP →	+0.696	+1.792	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	DNA2 →	+1.416	+1.279	.009	.002	3	4
LARGE_INTESTINE	ORMDL2 →	+0.798	+1.357	.005	.001	3	4
LUNG_SCLC	PRELID2 →	-2.416	-1.748	.004	<.001	3	4
SOFT_TISSUE	LSM12 →	-0.541	-1.231	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CEP72 by Protein repair activity — BONE

Explore this box plot interactively →