Protein repair

Across TCGA cell cohorts, RNA activity of the Protein repair pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBPL1, USP45, and HBS1L, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein repair activity versus TBPL1 in BLOOD_Leukemia (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TBPL1 →	+0.893	+0.123	<.001	.001	3	6
UPPER_AERODIGESTIVE_TRACT	USP45 →	+0.986	+0.275	.006	.006	3	6
LUNG_NSCLC_LUAD	HBS1L →	+0.760	+0.232	.002	.002	3	6
LUNG_SCLC	NUP43 →	+0.740	+0.274	.001	<.001	2	7
LUNG_SCLC	PCMT1 →	+0.671	+0.202	<.001	<.001	3	6
BLOOD_Leukemia	NANP →	+0.816	+0.153	.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030091 vs TBPL1 — BLOOD_Leukemia

Explore this scatter interactively →