Insulin secretion

Across TCGA patient cohorts, RNA activity of the Insulin secretion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPED1, MAMDC2, and CSDC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Insulin secretion activity versus CPED1 in BRCA (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CPED1 →	+0.844	+0.392	<.001	.001	3	3
BRCA	MAMDC2 →	+0.953	+0.345	.001	.002	3	3
BRCA	CSDC2 →	+0.799	+0.311	<.001	.001	3	3
LUAD	TMCC3 →	+1.038	+0.227	.002	<.001	2	4
LUAD	FRMD4B →	+1.011	+0.198	.001	.008	3	3
HNSC	SBF2-AS1 →	-0.566	-0.125	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030073 vs CPED1 — BRCA

Explore this scatter interactively →