Insulin secretion

Across TCGA cell cohorts, RNA activity of the Insulin secretion pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRSF12, FJX1, and ACAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRSF12 grouped by Insulin secretion-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SRSF12 →	+0.419	+0.731	.006	.002	3	4
PANCREAS	FJX1 →	-1.482	-0.969	.007	.008	3	4
LARGE_INTESTINE	ACAP1 →	-0.722	-0.906	.003	.003	3	3
OVARY	COL18A1 →	+1.887	+0.799	.002	<.001	3	3
BLOOD_Myeloma	NTNG2 →	-0.946	-1.872	.008	<.001	3	3
LIVER	HCST →	+0.490	+1.575	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRSF12 by Insulin secretion activity — SKIN

Explore this box plot interactively →