Insulin secretion

Across TCGA cell cohorts, RNA activity of the Insulin secretion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC159, NATD1, and DDTL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Insulin secretion activity versus CCDC159 in LUNG_SCLC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CCDC159 →	+1.076	+0.176	.002	.001	2	5
BLOOD_Lymphoma	NATD1 →	-0.874	-0.113	.004	.009	3	4
BLOOD_Lymphoma	DDTL →	+0.599	+0.124	<.001	.003	3	4
LUNG_NSCLC_LUSC	TMEM170B →	-0.755	-0.403	.009	.008	2	5
OESOPHAGUS	WARS2 →	-0.921	-0.317	.002	.001	3	4
PANCREAS	BCL7A →	-0.882	-0.255	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030073 vs CCDC159 — LUNG_SCLC

Explore this scatter interactively →