Insulin processing

Across TCGA patient cohorts, RNA activity of the Insulin processing pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLCN4, ERO1B, and LINC01133, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Insulin processing activity versus CLCN4 in HNSC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CLCN4 →	+0.646	+0.217	.001	<.001	3	4
LUAD	ERO1B →	+0.925	+0.273	<.001	<.001	3	4
LUAD	LINC01133 →	-0.843	-0.180	.002	.004	3	3
COAD	SATB2 →	-0.974	-0.138	.001	.005	3	3
OV	PTPRG →	-0.811	-0.135	<.001	.008	3	3
OV	CRPPA-AS1 →	-0.097	-0.135	.007	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030070 vs CLCN4 — HNSC

Explore this scatter interactively →