Insulin processing

Across TCGA cell cohorts, RNA activity of the Insulin processing pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERO1B, PCSK2, and SLC30A5, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ERO1B grouped by Insulin processing-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ERO1B →	-0.288	-1.756	.003	<.001	3	9
BREAST	PCSK2 →	-0.282	-1.231	<.001	<.001	3	9
BLOOD_Leukemia	SLC30A5 →	-0.194	-1.823	.001	<.001	3	4
LUNG_NSCLC_LUAD	TAS2R14 →	+0.162	+1.027	<.001	.001	3	4
OESOPHAGUS	PLPPR4 →	-0.158	-1.684	<.001	<.001	3	4
OESOPHAGUS	YIPF5 →	-0.243	-1.690	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ERO1B by Insulin processing activity — SOFT_TISSUE

Explore this box plot interactively →