Insulin processing

Across TCGA cell cohorts, RNA activity of the Insulin processing pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGFRL1, FBXO15, and NAA25, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Insulin processing activity versus FGFRL1 in CNS (Pearson r = -0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FGFRL1 →	-2.330	-0.186	.004	.002	3	3
CNS	FBXO15 →	+0.601	+0.168	.001	<.001	3	3
KIDNEY	NAA25 →	-0.647	-0.266	<.001	.004	3	3
LARGE_INTESTINE	RER1 →	+0.263	+0.171	.006	.003	3	3
LARGE_INTESTINE	H4C5 →	-0.861	-0.164	.002	.003	3	3
BLOOD_Leukemia	TMEM241 →	-0.805	-0.269	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030070 vs FGFRL1 — CNS

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