Actin filament-based movement

Across TCGA cell cohorts, RNA activity of the Actin filament-based movement pathway is significantly associated with the protein abundance of multiple proteins, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SUN2, RPL23, and RPL12, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin filament-based movement activity versus SUN2 in BONE (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SUN2 →	+1.736	+0.421	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	RPL23 →	-1.044	-0.376	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	RPL12 →	-0.837	-0.361	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	RPS17 →	-1.205	-0.364	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	PA2G4 →	-1.965	-0.349	<.001	<.001	3	10
BONE	MYO1C →	+1.435	+0.374	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030048 vs SUN2 — BONE

Explore this scatter interactively →