Parallel actin filament bundle assembly

Across TCGA patient cohorts, RNA activity of the Parallel actin filament bundle assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHAF1A, LIG1, and ATRX, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Parallel actin filament bundle assembly activity versus CHAF1A in LSCC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CHAF1A →	-0.366	-0.051	<.001	.002	3	5
GBM	LIG1 →	-0.367	-0.075	.009	.002	3	5
HNSC	ATRX →	-0.137	-0.065	.008	.004	3	5
CCRCC	GLIPR2 →	+0.269	+0.070	<.001	<.001	3	5
CCRCC	LGALS1_S30 →	+0.523	+0.095	.003	<.001	3	5
HNSC	PHIP →	-0.354	-0.110	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030046 vs CHAF1A — LSCC

Explore this scatter interactively →