Parallel actin filament bundle assembly

Across TCGA patient cohorts, RNA activity of the Parallel actin filament bundle assembly pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NTNG2, DAB2, and VSIG4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Parallel actin filament bundle assembly activity versus NTNG2 in GBM (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NTNG2 →	+0.651	+0.591	<.001	.001	3	4
LSCC	DAB2 →	+0.514	+0.085	<.001	.001	3	4
BRCA	VSIG4 →	+0.651	+0.275	.006	.006	3	4
LUAD	LINC01094 →	+0.511	+0.116	<.001	.005	3	4
BRCA	FSCN1 →	+0.691	+0.169	.005	.007	3	4
OV	FCGR2A →	+0.863	+0.309	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030046 vs NTNG2 — GBM

Explore this scatter interactively →