Parallel actin filament bundle assembly

Across TCGA cell cohorts, RNA activity of the Parallel actin filament bundle assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM5, SPIRE1, and OR2W3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM5 grouped by Parallel actin filament bundle assembly-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RBM5 →	-0.232	-1.303	.006	.005	2	5
SOFT_TISSUE	SPIRE1 →	-0.260	-1.698	.005	.001	2	5
CNS	OR2W3 →	-0.312	-1.679	.003	.001	3	4
STOMACH	PXMP4 →	-0.183	-1.226	.003	.005	3	4
LIVER	GZMM →	-0.301	-1.616	.002	<.001	3	4
LUNG_NSCLC_LUSC	CCL18 →	-0.176	-1.552	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM5 by Parallel actin filament bundle assembly activity — BLOOD_Leukemia

Explore this box plot interactively →