Parallel actin filament bundle assembly

Across TCGA cell cohorts, RNA activity of the Parallel actin filament bundle assembly pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPRD1A, MEST, and ANXA3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Parallel actin filament bundle assembly activity versus RPRD1A in LIVER (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RPRD1A →	+0.875	+1.751	.001	<.001	2	4
STOMACH	MEST →	-3.874	-2.338	.001	.007	3	3
BREAST	ANXA3 →	-3.888	-1.097	<.001	.007	3	3
LARGE_INTESTINE	CORO2A →	-1.426	-1.026	.005	.008	3	3
LUNG_SCLC	CHMP4B →	-0.794	-0.189	<.001	.001	3	3
LUNG_SCLC	ZNF519 →	+1.052	+0.209	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030046 vs RPRD1A — LIVER

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