Actin filament depolymerization

Across TCGA patient cohorts, RNA activity of the Actin filament depolymerization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, MAP1A, and RPL5, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin filament depolymerization activity versus RSU1 in BRCA (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RSU1 →	+0.345	+0.031	<.001	<.001	3	10
HNSC	MAP1A →	+0.511	+0.055	<.001	<.001	3	10
CCRCC	RPL5 →	-0.304	-0.069	<.001	<.001	3	9
HNSC	SEPTIN4_S432 →	+0.573	+0.073	<.001	<.001	3	9
UCEC	SEPTIN7 →	+0.290	+0.060	<.001	<.001	3	9
UCEC	SORBS1 →	+0.868	+0.079	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030042 vs RSU1 — BRCA

Explore this scatter interactively →