Actin filament depolymerization

Across TCGA patient cohorts, RNA activity of the Actin filament depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYL9, FHL5, and PDE1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin filament depolymerization activity versus MYL9 in BRCA (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MYL9 →	+1.025	+0.267	<.001	<.001	3	5
HNSC	FHL5 →	+0.880	+0.188	<.001	.002	3	4
UCEC	PDE1A →	+1.264	+0.404	<.001	.001	3	4
BRCA	MYCT1 →	+0.927	+0.315	<.001	<.001	3	4
HNSC	MYH2 →	+3.837	+0.240	<.001	<.001	3	4
HNSC	AOX1 →	+1.426	+0.186	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030042 vs MYL9 — BRCA

Explore this scatter interactively →