Actin filament depolymerization

Across TCGA cell cohorts, RNA activity of the Actin filament depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNN2, ADARB1, and CDK5RAP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNN2 grouped by Actin filament depolymerization-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CNN2 →	+1.354	+1.103	.007	.005	3	4
LUNG_NSCLC_LUSC	ADARB1 →	-1.101	-1.329	.001	.002	2	5
LUNG_SCLC	CDK5RAP3 →	-0.862	-1.024	.008	.008	2	5
BREAST	POLR3F →	-0.475	-0.881	.002	.001	3	4
BREAST	GPBP1L1 →	-0.678	-1.139	<.001	.005	3	4
LUNG_SCLC	RPS6KA5 →	-1.495	-1.125	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNN2 by Actin filament depolymerization activity — SOFT_TISSUE

Explore this box plot interactively →